Tuesday, November 10, 2015

Divergence in the Drug Businesses: Pharmaceuticals and Biotechnology

In the last two weeks, I have started writing about Pfizer’s courting of Allergan, the epic fall of Valeant and the unraveling of the Theranos story, but I have held back because all three stories have to be set against the backdrop of the changing health care business. While there are numerous stories being told about how this is changing, I decided that it made sense to start by looking at the evolution of the health care business over the last 25 years  and how changes in its core characteristics may explain all three stories.

The Story
To understand the drug business, I went back to 1991, towards the beginning of a surge in spending in the US on health care. The pharmaceutical companies at the time were cash machines, built on a platform of substantial up front investments in research and development. The drugs generated by R&D that made it through FDA approval and into commercial production were used to cover the aggregated cost of R&D and to generate significant excess profits. The key to this process was the pricing power enjoyed by the drug companies, the result of a well-defended patent system, significant growth in health care spending, splintered health insurance companies and lack of accountability for costs at every level (from patients to hospitals to the government). In this model, not surprisingly, investors rewarded pharmaceutical companies based on the amounts they spent on R&D (secure in their belief that the costs could be passed on to customers) and the fullness and balance of their product pipelines.

So, how has the story changed over the last decade? The rise in health care costs seems to have slowed down and the pricing power of drug companies has waned for many reasons, with Obamacare being only one of many drivers. First, we have seen more consolidation within the health insurance business, potentially increasing their bargaining power with the pharmaceutical companies on drug prices. Second, the government has used the buying clout of Medicaid to bargain for better prices on drugs, and while Medicare still works through insurance companies, it can put pressure on them to negotiate for lower costs. Third, the pharmacies that represent the distribution networks for many drugs have also been corporatized and consolidated, and are gaining a voice in the pricing process. The net effect of all of these changes is that R&D has much more uncertain payoffs and has to evaluated like any other large capital investment, that it is good only when it creates value for a business. Consequently, investors have had to become more measured in their judgment of R&D spending at drug companies, rewarding companies for spending more on R&D only if it is productive and punishing them when it is not.

The Operating Numbers
The diminished pricing power story is not a new one and others have made the points that I have but it is still just a story. The real question is whether the numbers back the story and to answer that question, I looked at key operating metrics for publicly traded drug companies from 1991 to 2014, with the intent of eking out trends in the numbers.
The Revenue Growth Story: The Rise of Biotech
The growth in health care costs continued into the last decade, albeit at levels much more moderate than in the 1990s, but the big story was the rise of biotechnology companies in the space. At inception, the distinction between pharmaceutical and biotech companies wass the method by which they produced drugs, with pharmaceutical firms working with chemicals and biotechnology companies using live organisms (bacteria, cells or yeast) to generate their drugs. Given that both R&D processes are designed to generate drugs that go through similar FDA approval processes and get sold through the same distribution channels, this difference is one that only scientists can relate to, and one that is becoming meaningless as R&D departments at both groups poach on the other's territory. The rest of the differences that people point to between the two, i.e, that biotech companies spend more time on research, tend to lose money and are riskier than pharmaceutical firms have less to do with business differences than life cycle differences.

In the picture below, I look at the aggregate revenues reported by pharmaceutical and biotechnology companies from 1991 to 2014.
Source: Classification by S&P Capital IQ
Note that by the last decade, and especially since 2010, almost all of the growth in the drug business has come from the biotech companies, with pharmaceutical companies reporting flat revenues between 2010 and 2014. In 2014, biotech companies accounted for 30.63% of total revenues at drug companies, up from 19.23% in 2010.


The generalization that biotech companies tend to be younger and earlier in the life cycle is being put to the test as some biotech companies age. In 2014, for instance, four of the top ten drug companies in the US, in revenues, were biotechnology companies.

Company NameIndustry ClassificationsRevenues in 2014
Johnson & Johnson (NYSE:JNJ)Pharmaceuticals (Primary)$74,331.00
Pfizer Inc. (NYSE:PFE)Pharmaceuticals (Primary)$49,605.00
Merck & Co. Inc. (NYSE:MRK)Pharmaceuticals (Primary)$42,237.00
Gilead Sciences Inc. (NasdaqGS:GILD)Biotechnology (Primary)$24,890.00
Amgen Inc. (NasdaqGS:AMGN)Biotechnology (Primary)$20,063.00
AbbVie Inc. (NYSE:ABBV)Biotechnology (Primary)$19,960.00
Eli Lilly and Company (NYSE:LLY)Pharmaceuticals (Primary)$19,615.60
Bristol-Myers Squibb Company (NYSE:BMY)Pharmaceuticals (Primary)$15,879.00
Allergan plc (NYSE:AGN)Pharmaceuticals (Primary)$13,062.30
Biogen Inc. (NasdaqGS:BIIB)Biotechnology (Primary)$9,700.30
In fact, many of these companies have blurred the line between pharmaceutical and biotechnology companies further, and some like Pfizer describe themselves as biopharmaceutical companies.

The Money Machine: Profitable but for how long?
In keeping with the hgh pricing power story, pharmaceutical companies have always been able to enjoy sky-high operating margins, a fact rendered even more impressive by the fact that the accounting at these companies treats R&D, the biggest capital expenditure that these firms have, as an operating expense (thus depressing reported profits and margins). In the graph below, I look at the evolution of operating margins at pharmaceutical and biotech companies from 1991 to 2014, using two measures, one looking at operating profit (EBIT) as a percent of sales and one with R&D added back to operating income (EBITR&D) estimates as a proportion of sales.
Ratios based on aggregated values of Sales, EBIT and R&D
On the surface, at least, no one will shed tears for pharmaceutical companies since companies in most other sectors would gladly trade for their margins. In fact, while operating margins for pharmaceutical companies have dropped from their highs in 2001 and 2002, they are not very different from what they were in the 1990s. The story again, though, is in the biotech space, where companies have moved from losing money in the early 1990s to collectively generating higher margins than pharmaceutical firms, with the difference being even more pronounced on a pre-R&D basis.

The Payoff to R&D: No longer a slam dunk!
The argument for spending money on R&D has always been a simple one. By investing in R&D, you are investing for future growth and it is an equation that has held well for much of the last 25 years. In the table below, I report revenue growth and R&D expenses as a percent of sales each year for pharmaceutical and biotech companies each year from 1991 to 2014.


 Pharma
 Biotech
YearR&D/SalesRevenue GrowthGrowth to R&DR&D/SalesRevenue GrowthGrowth to R&D
199110.17%49.30%4.8526.22%1444.23%55.08
199210.64%6.40%0.6023.80%82.91%3.48
199310.97%3.58%0.3326.87%48.36%1.80
199410.30%15.85%1.5433.50%27.66%0.83
199510.37%17.32%1.6731.72%42.99%1.36
199610.44%11.38%1.0934.18%18.61%0.54
199710.61%13.20%1.2437.80%14.23%0.38
199811.15%19.92%1.7933.44%21.49%0.64
199911.08%15.66%1.4137.39%0.32%0.01
200011.41%8.15%0.7138.46%4.79%0.12
200113.74%-8.17%-0.5940.23%11.96%0.30
200213.95%4.80%0.3439.19%11.34%0.29
200314.72%16.26%1.1033.86%44.21%1.31
200414.79%8.17%0.5533.43%35.49%1.06
200515.40%1.49%0.1031.43%19.26%0.61
200616.08%2.86%0.1833.49%19.43%0.58
200716.21%8.57%0.5333.76%14.29%0.42
200815.94%6.21%0.3930.35%15.20%0.50
200915.58%-4.87%-0.3122.18%54.79%2.47
201015.17%19.82%1.3121.25%11.42%0.54
201114.30%3.77%0.2619.19%22.76%1.19
201214.48%-2.99%-0.2119.53%10.52%0.54
201314.28%2.34%0.1620.80%10.50%0.51
201414.36%1.67%0.1219.04%29.59%1.55
1991-9510.49%18.49%1.8028.42%329.23%12.51
1996-0010.94%13.66%1.2536.26%11.89%0.34
2001-0514.52%4.51%0.3035.63%24.45%0.71
2006-1015.80%6.52%0.4228.21%23.02%0.90
2011-1414.36%1.20%0.0819.64%18.34%0.95
I know that there is a substantial lag between R&D spending and revenue growth, but as a simplistic measure of the contemporaneous payoff to R&D, I computed a growth to R&D ratio:
Growth to R&D Ratio = Revenue Growth Rate/ R&D Spending as percent of sales
Notwithstanding its limitations, this ratio illustrates the biggest divergence between the two subsectors, dropping close to zero for pharmaceutical firms from 2010-14 time period, while remaining relatively healthy (though lower then in earlier periods) for biotech companies. 

What does this all mean? First, this table suggests that pharmaceutical companies have not cut back on internal R&D spending as much as some stories suggest that they have and that much of the slack has been picked up by biotech companies. Second, this table also suggests that pharmaceutical companies should be spending less money on R&D, not more, as the growth payoff to R&D becomes lower and lower. Third, it provides at least a partial explanation for why some pharmaceutical companies have embarked on the acquisition path, focusing on buyer younger, smaller companies for the products in their research pipeline. 

The Pricing
As the operating metrics for pharmaceutical and biotech companies have changed, the market has also adjusted to reflect these changes, though the argument always can be made that it has adjusted too slowly and not enough or too fast and too much.

Market Capitalization
If markets are assessing companies on fundamentals, the market capitalization should reflect everything that we have talked about in the last section. Rather than take that on faith, I looked at the aggregate market capitalizations of pharmaceutical and biotechnology companies from 1991 to 2014:
Aggregate Market Capitalization at end of each calendar year

In 2014, biotechnology companies accounted for 38.16% of the total market capitalization of drug companies, up from 26.87% of value in 2010.

EV Multiples
Bringing the changes in operating metrics and market value over time into one measure is difficult partly because biotechnology companies have lost money for the bulk of the last 25 years. The only multiple that can be computed for both groups is the ratio of enterprise value ( to earnings before interest, taxes and R&D (EBITR&D) and the graph below captures the shifts over time:
Biotech companies traded at huge multiples in the late 1990s, partly because they earned so little and were being priced for future growth. As they have became larger contributors to earnings in the drug business, the multiple at which they trade has come down and both groups traded at roughly similar multiples of EBITR&D in 2008 and 2009. Since 2010, though, the multiple of EBITR&D at which biotech companies trade has risen relative to pharmaceutical companies.

The Aging of the Drug Business
As many of you have been reading this blog know, one of my favorite devices for explaining shifts in businesses and companies is the corporate life cycle. As companies age, not only should the focus change but so will the way investors judge them:

Just as the aging of technology companies has created more diversity in that space, an argument that  I made in this post, the health care business is showing signs of aging. The older, more established companies in the business, for the most part, are in their mature phases, and not surprisingly, their focus has shifted to consolidation, capital structure changes and tax management. The younger companies in the space will increasingly carry the burden of investing for growth, but will have to be far more disciplined in their R&D spending than their older counterparts were two decades ago. If health care cost growth continues to be contained and drug company pricing power remains muted, you should expect to see less aggregate spending on research and development at drug companies. While that will undoubtedly provoke hand wringing on the part of experts, pundits and politicians, it is the logical consequence of a changing health care landscape.

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8 comments:

Venkat Subramaniam said...

Thank you Ashwath. As always, your blog is enriching. The increasingly tenuous link between R&D spend and revenue growth prospects made me think about the reasons; and the following points came to mind:
1. May be in years gone by, a lot of discoveries were left to be made, hence, most R&D spend turned into successful products; now, most of the easy discoveries, using the knowledge/know-how humans have, have been made.
2. That said, there are areas where human know-how is likely to achieve a break-through due to increased research being carried out by Govt's and academia - most notably in neuroscience. May be if/when our understanding of the workings of our brain achieves a break-through, private sector R&D seeking to exploit this break-through will suddenly achieve a greater degree of success with respect to new products. Neuroscience is one example, I am sure humans are yet to learn a lot about the workings of our bodies.
3. Following on from the above, may be the link between R&D and revenue growth itself is cyclical - i.e., it achieves sudden positive busts every time we learn something new about our body, such that it leads to more likely R&D success in that area, leading to multiple product breakthroughs. As an analogy, although there was no private sector or big pharma to monitize this, imagine the amount of new/better medicines humans developed in the last 2 centuries compared to the previous 2, simply because of better understanding of the human body.

The upshot of the above is, may be the link between R&D and revenue might come back again. May be not for the same firms, may be for completely different/new firms. Who knows. But my bet is that it will. And a breakthrough in neuroscience is probably the most likely area.

Once again, grateful for your blogs. I get to learn something new every time I read one.

Anonymous said...

You are on to something when you talk about aging companies. Pfizer being an example.
You are off however when you talk about reducing R&D. Without R&D and continuous
improvement today's new age companies will age prematurely.

Yehuda Fruchter said...

Thoughtful blog as always. But...

"The rise in health care costs seems to have slowed down and the pricing power of drug companies has waned for many reasons." Seriously? I can only imagine you work for a large university that pays all your health insurance :0). Also, I have to imagine you have been lucky to have not had to have any serious medical procedure in recent years and don't take any life-saving drugs. From real-world experience, I can tell you that health care costs have not slowed one bit. In fact, they are accelerating. It's just hidden in clever fashions (e.g. exponential rises in deductibles, narrow physician networks, indecipherable medical bills).

BTW, it is illegal for Medicare, the largest buyer of drugs in the world, to negotiate drug prices (2003 Medicare Modernization Act). Relying on private insurers to negotiate pricing is kind of like asking a bank robber to become the bank security guard. It is also a well known fact, that the same exact drugs are sold in Canada, and any other country for that matter, at a fraction of the cost of US prices, but is illegal to buy these same drugs in Canada, if you live in the US. Under the Orwellian view of capitalism espoused by drug and health care companies, competition, negotiation for better prices, and a free market are all evil Socialist principles.

Yehuda Fruchter said...

I might also point out that trying to tie serious R&D to revenue, belies a serious misunderstanding of the purpose R&D, and how the medical industry actually works from a business perspective nowadays. Without basic R&D for which financial considerations play no role and profit motives are downright injurious to discovery, there would be no scientific or medical advancement in any field whatsoever. I wonder if Watson and Crick thought about how they could make money out of this double-helix thingy, as they attempted to unravel the mysteries of DNA? Did Einstein ponder the billions he could make on commercial applications, while ruminating on theory of relativity? Did Jenner think about how much he could charge consumers, while he embarked on ridding the world of smallpox?

Mike said...

Thanks Professor, your blog is always a learning experience. I was curious about how you considered both mergers & acquisitions/consolidation as well as companies that have not survived over the past 25 years in your data set? By using only the surviving companies today, is the data screwed in a certain direction?

R&D spend in the pharma industry is crucial to new product development since the exclusivity period is limited and the generic erosion is intense thereafter. I do think that companies will need to be smarter and more focused in their R&D spend. However, I do think there is a benefit of investing heavily on R&D at least in the short-to-mid term (as pricing pressure, regulatory, and political factors continue to unfold) in areas of unmet medical needs such as oncology and hep C. It seems that investors are more concerned with the immediate noise in the industry and pricing pharmas accordingly. Do you think that this is definitely a life cycle trend or potentially short-term noise?

Thanks and I look forward to your next blog.

HelicalZz said...

The trouble here, as you point out, has always been the distinction between the two segments, biotechnology and pharmaceutical. I agree that this distinction was initially one of small molecule therapeutics and biotherapeutics (protiens, MABs, etc.). But today, a pharmaceutical firm like J&J derives a much higher % of its revenues from biotherapeutics than biotechnology leader Gilead, the small molecule antiviral powerhouse. The biotechnology industry was birthed after 1980 with two key events, the Diamond v. Chakrabarty Supreme Court Decision and the Bayh-Dole act. Before these, biotechnology meant laboratory instruments. Today, biotechnology seems to mean any 'development stage' therapeutic firm, and those revenue generating firms that were founded after 1980. It is a separation that has outlived its usefulness, and blurs the more relevant distinction of firms that are 'development stage' and those with marketable products approved.

Divesh said...

Hi Professor,

Excellent article. To supplement your findings, may I recommend McKinsey's analysis on the fragmentation within the pharmaceutical industry due to: a) lack of pricing power, and b) lack of innovation at the big firms.

http://www.mckinsey.com/insights/health_systems_and_services/a_wake-up_call_for_big_pharma

Anonymous said...

Professor Damodaran:

Remember that you promissed for this year to complete the 10 DCF Myths. You have only given us 2 myths so far.

Thanks.